01 - Pat the shrimp dry with paper towels, then season evenly with kosher salt and black pepper.
02 - Arrange three shallow bowls: combine flour, cornstarch, garlic powder, and smoked paprika in the first; beat eggs in the second; place panko breadcrumbs in the third.
03 - Dredge each shrimp in the flour mixture, shaking off excess. Dip into beaten egg, then press firmly into panko to coat completely.
04 - Pour 2 inches of vegetable oil into a deep skillet or Dutch oven. Heat to 350°F.
05 - Fry shrimp in batches for 2 to 3 minutes, turning halfway through, until golden brown and crispy. Transfer to a paper towel-lined plate to drain.
06 - In a small saucepan over low heat, melt butter with honey, hot sauce, and red pepper flakes. Stir constantly until combined and heated through, about 2 minutes.
07 - Toss fried shrimp in the hot honey glaze until evenly coated. Serve immediately, garnished with fresh chives or parsley and lemon wedges.